| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
Plasma miR-1273g-3p acts as a potential biomarker for early Breast Ductal Cancer diagnosis
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| Autores: |
Guo,Huan
Zeng,Xiangting
Li,Haining
Guo,Yanxiang
Wang,Tao
Guo,Hongyun
Zhu,Gongjian
Wang,Lan
Zhou,Haihong
Liu,Kedan
Chen,Xiaoyi
Wang,Haitao
Zhao,Xinke
Su,Haixiang
Li,Yingdong
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| Data: |
2020-01-01
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| Ano: |
2020
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| Palavras-chave: |
Breast ductal carcinoma
Plasma
MiR-1273g-3p
Circulating miRNA
Biomarker
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| Resumo: |
Abstract Circulating miRNAs presenting in plasma in a stable manner have been demonstrated their potential role as a promising biomarkers in many human diseases, such as Alzheimer’s disease, melanoma and ovarian carcinoma. However, few circulating miRNAs could be used for breast ductal cancer diagnosis. Here, we identified miR-1273g-3p as a biomarker for detecting breast ductal cancer. We detected miR-1273g-3p levels in the plasma of 39 sporadic breast ductal cancer patients and 40 healthy donors by Stem-loop Quantitative Real-time PCR (qRT-PCR). The results showed the plasma miR-1273g-3p level were significantly up-regulated in breast ductal cancer patients compared with healthy donors (p=0.0139). Receiver operating characteristic (ROC) curve also revealed the significantly diagnostic ability of miR-1273g-3p in patients (p=0.0414). In addition, the plasma level of miR-1273g-3p was closely related to IIIB-IIIC TNM stage. We also confirmed the higher expression level of miR-1273g-3p in breast cancer cell lines MCF-7 (4.872±0.537) than normal breast cells (Hs 578Bst). Taken together, miR-1273g-3p could represent as a potential biomarker for early breast ductal cancer diagnosis.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100801
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/0001-3765202020181203
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.92 n.1 2020
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| Direitos: |
info:eu-repo/semantics/openAccess
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